Moderna Covid Vaccine Update: Is the Moderna Vaccine Safe? Allergic Reactions and Side Effects

is the moderna vaccine safe what are the side 
effects allergic reactions guillain-barre syndrome   bell's palsy let's break it down in this video 
so the moderna they took the genetic code from   the sars coronavirus 2 virus they identify 
the section that codes for the spike protein   the protein that binds to human ace2 receptor 
and they use this mrna sequence for its vaccine   short additional genetic sequences were 
added to both ends to help stabilize   this mrna the mrna strands are encapsulated in 
a lipid nanoparticle what is especially nice   about messenger rna vaccines is that there are 
no weakened killed or gutted viral particles in   the vaccine making it much safer for those who are 
immunocompromised and this vaccine is 95 effective   so like the pfizer bio and tech vaccine 
there are two doses with the moderna vaccine  they're administered on days 1 and day 29 so 
it's a little bit different from pfizer pfizer's   first one and then you get the second one three 
weeks later so very similar once the messenger   rna vaccine is injected human cells that used the 
mrna code to produce a viral spike protein but   not the other 28 proteins required to make a sars 
cov2 virus without the complete genetic code the   sars-kov2 virus can't be manufactured in a human 
being once the viral spike protein is produced the   human immune system recognizes it as foreign then 
there's a series of complicated immune processes   including the production of antibodies that 
are triggered and that's what allows your body   to fight off that virus in the future so in the 
new england journal medicine moderna enrolled   over 30 000 volunteers age 18 and older and 
it's a double-blinded placebo-controlled study   eleven thousand were from communities of 
color seven thousand were 65 and older   and there were 5 000 that were under the age of 
65 but they had conditions that were considered   risk factors for severe covid half the people 
received the vaccine half the people received   placebo so 15 000 and placebo group 15 000 who got 
the vaccine symptomatic covid 19 was confirmed in   185 people in the placebo group and only 11 in 
the vaccinated group so that's a 94.1 percent   efficacy now researchers actively monitored 
the vaccine recipients for local and systemic   side effects for seven days after vaccination and 
they recorded unsolicited side effects for 28 days   and more severe side effects and medically 
attended adverse events from day one all the way   through day 759 which means it's continuing to be 
monitored let's first start off by talking about   the local side effects so injection site reactions 
in the seven days after the first vaccination dose   that occurred in 84 of the vaccinated group and 
that's compared to 20 percent in the placebo after   the second dose 89 of the vaccinated group and 
19 of the unvaccinated group recorded injection   side effects overall the vaccine side effects 
were rated as mild to moderate in severity   and lasted an average of 2.6 and 3.2 days after 
the first and second vaccine doses respectively   the most common local side effect was injection 
site pain that was reported 84 percentage and 88 percentage in the   vaccinated group after the first and second 
vaccine dose respectively injection site pain   was reported by 20 percent and 17 of the placebo 
group after the first and second dose the average   duration of pain was two days after the first 
dose and three days after the second swollen   axillary lymph nodes meaning lymph nodes 
and your armpits they were swollen and 21   of people under the age of 65 and 12 percent of 
people over the age of 65 in the vaccine group   and then it was about five percent in four 
percent of individuals in the placebo group the   median duration of swelling was one day after 
the first dose in two days after the second   other local side effects were uncommon such 
as redness and swelling at the injection site   so what about systemic side effects just like with 
the pfizer vaccine systemic side effects were more   common after the second vaccine with 55 percentage reporting 
a systemic side effect after the first dose   and 79 after the second dose in the vaccine 
group in the placebo group 42 percentage had side effects   that were systemic after the first dose and 37 
after the second dose the most commonly reported   systemic adverse event was fatigue that was at 69 
percent of the vaccine group and 36 of the placebo   and that fatigue lasted for about a couple 
days headache was reported in 63 in the   vaccine group and then 37 at the placebo group 
muscle pain was reported 60 in the vaccine   20 in the placebo group now in the vaccine group 
45 reported joint pain compared to 17 and placebo   then there was other things that occurred less 
frequently but more commonly in the vaccine group   such as chills and fever about half of those 
in the vaccinated group reported systemic side   effects starting at 15 hours after vaccination 
with no long-term side effects systemic reactions   lasting longer than seven days were about 12 
percent in the vaccine that's compared to 10   percent in the placebo so about the same in both 
groups severe adverse reactions defined as those   that prevent normal daily activities that was 
0.2 to 7.7 percent of participants overall   fewer than one percent of vaccine recipients 
reported fever over 102 degrees fahrenheit   severe fatigue was reported in 7.7 of vaccine 
recipients muscle pain and 6.1 joint pain in 3.7   and headache in 4.4 severe adverse reactions 
were more frequently reported after the second   vaccine dose and less commonly in the groups that 
were over 65 years old systemic side effects are   expected as the immune system responds to foreign 
viral proteins so a decrease in reactorgenicity is   expected in older adults as aging brings about 
a gradual deterioration in the immune response   however the immune response or reactogenicity 
of the immune system to the moderna vaccine   it may be more than most people have previously 
experienced with other vaccines so in summary   just like with pfizer those who were younger less 
than the age of 65 they had more frequent mild to   moderate side effects compared to the older groups 
the safety profile was similar across age groups   genders ethnic and racial groups participants with 
or without comorbid conditions and participants   with or without evidence of prior covid infection 
these systemic side effects are unpleasant and   are at a higher rate than seen in most vaccines 
and in most cases they're more likely related   to the lipid nanoparticles that have super tiny 
amounts of polyethylene glycol moderna reported no   anaphylactic or severe allergic reactions to 
the vaccine but a hypersensitivity reaction   was reported in 1.5 percent of vaccine 
recipients and that's compared to 1.1   percent of placebo recipients the fda's website 
has the list of ingredients found in all vaccines   and advises that people with a history of severe 
allergic reactions check the list and discuss the   risk of vaccination with their own doctor so there 
was a boston physician who had a severe allergic   reaction to the moderna vaccine he did have a 
history of having allergic reaction to shellfish   and he was rushed to the emergency 
room he was treated and released   also it was initially recommended that pregnant 
women or those who intend to become pregnant in   three months should not get the vaccine due 
to the lack of their inclusion in the studies   but the american college of obstetricians and 
gynecologists has recently released a statement   supporting vaccination for both 
pregnant and breastfeeding mothers   bell's palsy was observed in three people in the 
vaccinated group and one in the placebo group   bell's palsy is a condition that causes temporary 
weakness or paralysis in the muscles on one side   of the face it's frequently a reaction to a viral 
infection a recent study in italy reported that   out of 38 people presenting to a local er for 
symptoms that were consistent with bell's palsy 21   had covid 19 in 2019 at that same er 22 people 
were treated for bell's palsy bell's palsy usually   resolves on its own within 6 months the incidence 
of bell's palsy as a side effect from the vaccine   will be tracked and compared to the incidence of 
bell's palsy in the unvaccinated population   Guillain beret syndrome which is a neurological disorder 
that can cause muscle weakness or even paralysis   has not been reported during coronavirus vaccine 
clinical trials and in general the advisory   committee on immunization practices does not list 
a history of guillain-barre syndrome as a general   vaccination precaution with the latest guideline 
the only people who should not get the vaccine are   those who are known to be allergic to any of his 
ingredients which is a cut off that holds true for   every single medical product ingredients include 
lipid nanoparticles and polyethylene glycol   anaphylactic reactions can occur with any vaccine 
but are usually extremely rare about one per one   million doses as of december 19th the united 
states has seen six cases of anaphylaxis among   272 000 people who received the covid 19 vaccine 
and there were two recorded cases in the uk as   with everything we do whether it's driving a 
car to eating a food that could potentially be   allergenic we have to weigh the risks versus 
the benefits and when it comes to covid 19   the risks of getting covid 19 and the 
potential consequences that come with that   far outweigh the risks that 
come from the vaccine itself  

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